Greenblatt has served as the CEO of the Anti-Defamation League (ADL) since 2015.

The ADL is an international Jewish non-governmental organization that advocates and acts on behalf of the Jewish people.

• In 2002, Greenblatt founded Ethos Water, a premium bottled water company that uses its profits to provide children with clean access to water. Greenblatt later served as a special assistant to President Obama in the White House.